Search results for "Repeated treatment"

Outcomes of pneumatic dilation in achalasia: Extended follow-up of more than 25 years with a focus on manometric subtypes

2018

Background and aim Pneumatic dilation (PD) is the most popular nonsurgical treatment for achalasia. This study investigated predicting factors, including manometric subtypes for symptom recurrence in the long term, in patients with achalasia treated with a single PD. Methods Between 1983 and 2013, a total of 107 patients were treated initially with a single PD and included in this longitudinal cohort study. Outcomes were correlated with demographics, symptoms (Eckardt score), and esophagographic and manometric features. Manometric tracings were retrospectively classified according to the three subtypes of the Chicago classification. Results Ninety-one (85%) patients were successfully treate…

Individual differences in the induction of sensitisation or tolerance to the motor effects of morphine in mice

2001

Acute morphine administration produces hyperactivity in most strains of mice and some studies indicate that repeated treatment can induce a potentiation of this effect (sensitisation). With the object of determining whether the hyperactivity induced by morphine in OF1 mice shows sensitisation after repeated administration, we tested the effect of the pre-exposure to six daily injections of morphine on the subsequent hyperactivity induced by the same dose of this drug. Animals were treated with 40 mg/kg of morphine for seven days. After the last injection they were tested in an actimeter at different points at time (15, 30, 45 and 60 min). This repeated schedule of treatment produced sensiti…

Head-twitch and forepaw-shake responses after single and repeated treatment with rolipram: interaction with noradrenergic and dopaminergic agonists a…

1988

A specific anti-aggressive effect of repeatedly administered lobeline.

2002

The effects of chronic treatments with nicotinic agonists on agonistic encounters have received little attention. The effects of repeated (for 10 days) SC administration of (-)-lobeline (9.3, 18.6 and 37.2 micromol/kg) and (-)-nicotine (0.93, 1.86 and 3.72 micromol/kg) were evaluated using the mouse isolation-induced aggression model. Individually housed OF1 male mice served as experimental animals and were confronted by 'standard opponents'. Each mouse was tested only once on the last day of the repeated drug treatment. Videotaped agonistic encounters were analysed estimating the times allocated to 11 behavioural categories. Repeated treatment with the highest dose of lobeline diminished a…